Publications

Orlanski S, Labi V, Reizel Y, Spiro A, Lichtenstein M, Levin-Klein R, Koralov SB, Skversky Y, Rajewsky K, Cedar H, Bergman Y. Tissue-specific DNA demethylation is required for proper B-cell differentiation and function. PNAS 2016, May 3;113(18):5018-23.

Lindhal LM, Fedholm S, Joseph C, Nielsen BS, Jonson L, Willerslev-Olsen A, Gluud M, Blümel E, Petersen DL, Sibbesen N, Hu T, Krejsgaard T, Jæhger D, Persson JL, Mongan N, Wasik MA, Litvinov IV, Sasseville D, Koralov SB, Bonefeld CM, Geisler C, Woetmann A, Ralfkiaer E, Iversen L, Ødum N. STAT5 induces miR-21 expression in cutaneous T cell lymphoma. Oncotarget. 2016, Jun 18.

Segal LN, Clemente JC, Tsay JJ, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD. Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nature Microbio. 2016, Apr 4;1:16031.

Coffre M, Benhamou D, Rieb D, Blumenberg L, Snetkova V, Hines M, Chakraborty T, Bajwa S, Jensen K, Chong MW, Getu L, Silverman GJ, Blelloch R, Litman DR, Melamed D, Skok J, Rajewsky K, Koralov SB. miRNAs are essential for the regulation of the PI3K/AKT/FOXO pathway and receptor editing during B cell maturation. Cell Rep. 2016 Nov 22;17(9):2271-2285.

Fredholm S, Litvinov IV, Mongan NP, Schiele S, Willerslev-Olsen A, Petersen DL, Krejsgaard T, Sibbesen N, Nastasi C, Bonefeld CM, Persson JL, Straten PT, Andersen MH, Koralov SB, Wasik MM, Geisler C, Sasseville D, Woetmann A, Ødum N. The Expression of IL-21 Is Promoted by MEKK4 in Malignant T Cells and Associated with Increased Progression Risk in Cutaneous T-Cell Lymphoma. J Invest Dermatol. 2016 Jan 21. Epub ahead of print.

Willerslev-Olsen A, Krejsgaard T, Lindahl LM, Litvinov IV, Fredholm S, Petersen DL, Nastasi C, Gniadecki R, Mongan NP, Sasseville D, Wasik MA, Bonefeld CM, Geisler C, Woetmann A, Iversen L, Kilian M, Koralov SB, Odum N. Staphylococcal enterotoxin A (SEA) stimulates STAT3 activation and IL-17 expression in cutaneous T-cell lymphoma. Blood. 2016 Mar 10;127(10):1287-96. doi: 10.1182/blood-2015-08-662353. Epub 2016 Jan 5.

Pylayeva-Gupta Y, Das S, Handler JS, Hajdu CH, Coffre M, Koralov SB, Bar-Sagi D. IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia.
Cancer Discov. 2016 Mar;6(3):247-55. doi: 10.1158/2159-8290.CD-15-0843. Epub 2015 Dec 29.

Wright KL, Adams JR, Liu JC, Loch AJ, Wong RG, Jo CEB, Beck LA, Santhanam DR, Weiss L, Mei X, Lane TF, Koralov SB, Done SJ, Woodgett JR, Zacksenhaus E, Pingzhao H and Egan SE. Ras signaling is a key determinant for metastatic dissemination and poor survival of luminal breast cancer patients. Cancer Res. 2015 Sep 23 Epub ahead of print.

Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L and Rao A. Simultaneous deletion of Tet1 and Tet3 increases transcriptome variability in early embryogenesis. PNAS 2015 Aug 4; 112(31):E4236-45.

Zhang B, Calado DP, Wang Z, Fröhler S, Köchert K, Qian Y, Koralov SB, Schmidt-Supprian M, Sasaki Y, Unitt C, Rodig S, Chen W, Dalla-Favera R, Alt FW, Pasqualucci L, Rajewsky K. An oncogenic role for alternative NF-?B signaling in DLBCL revealed upon deregulated Bcl6 expression. Cell Rep. 2015, May 5; 11(5):715-26

Danielson LS, Reavie L, Coussens M, Davalos-Vega V, Castillo-Martino M, Guijarrow M, Coffre M, Cordon-Cardo C, Aifantis I, Ibrahim S, Liu C, Koralov SB* and Hernando E*. Limited miR-17~92 overexpression drives hematologic malignancies. Leuk Research. 2014, Dec 10 [Epub ahead of print] doi: 10.1016/j.leukres.2014.12.002 (* co-corresponding authors)

Sun A, Novobrantseva TI, Coffre M, Hewitt SL, Jensen K, Skok JA, Rajewsky K and Koralov SB. VH replacement in primary immunoglobulin repertoire diversification. PNAS 2015, Feb 3; 112(5):E458-66.

Backer I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Wittkopf N, Brecht K, Waldner M, Neurath MF, Becker C and Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22 mediated epithelial host defense during infectious colitis. J Immunol. 2014 Oct 1; 193(7):3779-91.

Krejsgaard T, Willerslev-Olsen A, Lindahl LM, Bonefeld CM, Koralov SB, Geisler C, Wasik MA, Gniadecki R, Kilian M, Iversen L, Woetmann A, Odum N. Staphylococcal enterotoxins promote lymphoma-associated immune dysregulation by modulating benign and malignant T-cell interactions. Blood 2014 Jul 31; 124(5):761-70.

Kaplinsky J, Li A, Sun A, Coffre M, Koralov SB* and Araout R*. Antibody repertoire deep-sequencing reveals antigen-independent selection in maturing B cells. PNAS 2014, Jun24;111(25): 2622-9. *equal contribution

Carlson TJ, Pellerin A, Koralov SB, Rao A and Sundrud MS. Halofuginone-induced amino acid starvation regulates IL-23-dependent Th17 effector function and ameliorates established autoimmune inflammation. J Immunol. 2014 Mar 1; 192(5):2167-76.

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derruder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola SS, Rajewsky K and Koralov SB. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol. 2013 Sep 15; 191(6):3100-11

Krejsgaard T, Litvinov IV, Wang Y, Xia L, Willerslev-Olsen A, Koralov SB, Kopp KL, Bonefeld CM, Wasik MA, Geisler C, Woetmann A, Zhou Y, Sasseville D and Odum N. Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. Blood 2013 Aug 8;122(6):943-50.

Ko M, Bandukwala HS, Ana J, Lamperti ED, Thompson EC, Hastie R, Tsangaratou A, Rajewsky K, Koralov SB, and Rao A. Ten-eleven-translocation 2 (Tet2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. PNAS 2011 Aug 30; 108(35): 14566-71.

Arnaout R, Lee W, Cahill P, Honan T, Sparrow T, Weiand M, Nusbaum C, Rajewsky K and Koralov SB High-resolution description of antibody heavy-chain repertoires in humans. PLOS One 2011 Aug 6(8):e22365

Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 2009 Jun 5;324(5932):1334-8. PMCID: PMC2803727.

Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, Jensen K, Cobb BS, Merkenschlager M, Rajewsky N, Rajewsky K. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008 Mar 7;132(5):860-74.

Mesaros A*, Koralov SB*, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab. 2008 Mar;7(3):236-48. *equal contribution

Koralov SB, Novobrantseva TI, Königsmann J, Ehlich A, Rajewsky K. Antibody repertoires generated by VH replacement and direct VH to JH joining. Immunity. 2006 Jul;25(1):43-53.

Koralov SB, Novobrantseva TI, Hochedlinger K, Jaenisch R, Rajewsky K. Direct in vivo VH to JH rearrangement violating the 12/23 rule. J Exp Med. 2005. 7;201(3):341-8. PMCID: PMC1237122.